Retriever

Fat mutant labradors FAQ

10 days ago   |   By Dog Zombie

The study about a mutation associated with obesity in labrador retrievers has received massive news coverage for a dog genetics article (and you can see how happy the researchers are about it at GODogsProject ). So what does it mean for your dog?
Image: Raffan et al., 2016
Do all labs have this mutation? No. They tested 383 UK labs and found that of 383 Labrador retrievers from the UK, 78% of them didn't have this mutation at all; 20% had one copy of the mutation ; and 2% had two copies (the maximum number you can have; they were homozygous). They tested some US labs as well and found...
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Geek version of the fat mutant labs FAQ

Geek version of the fat mutant labs FAQ

10 days ago   |   By Dog Zombie

In the face of overwhelming demand (three people thought it sounded like a good idea), here is the geek version of the fat mutant labs FAQ , the nitty gritty about the study findings.
What gene is mutated and what does it do? The gene itself is one of these weird ones that actually codes for multiple proteins. (Basic genetics usually assumes that one gene codes for one protein, of which there may be a few different but similar versions.) The gene in this study is POMC, or proopiomelanocortin. The “pro” means that it codes for a protein which doesn't itself do anything until it gets cut up...
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